Reactome | ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit

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ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit Show undefined attributes

catalystActivity	[CatalystActivity:10910153] ubiquitin-protein transferase activity of ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910155
displayName	ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit
eventOf	[Pathway:R-DME-9954716] ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-9948291] RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-9948301] ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit - Homo sapiens
input	8 × [Complex:R-DME-8953915] Ub:UBE2D1,2,3 [cytosol] [Complex:R-DME-9948313] ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit
output	9 × [EntityWithAccessionedSequence:R-DME-174236] eff [cytosol] [Complex:R-DME-9948321] K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol]
precedingEvent	[Reaction:R-DME-9948317] ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9948301
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9954716] ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
(precedingEvent)	[Reaction:R-DME-9948291] RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide
(inferredTo)	[Reaction:R-HSA-9948301] ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit

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