Reactome | CDH1 forms homotypic trans-dimers

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CDH1 forms homotypic trans-dimers Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10909611
displayName	CDH1 forms homotypic trans-dimers
eventOf	[Pathway:R-DME-9958825] Activation of STAT3 by cadherin engagement - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9934410] CDH1 forms homotypic trans-dimers - Homo sapiens
input	120 × [SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [Complex:R-DME-9934501] Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] [Complex:R-DME-9934440] trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CDH1 forms homotypic trans-dimers
output	[Complex:R-DME-9934435] Homotypic CDH1 trans-dimer cluster [plasma membrane]
precedingEvent	[Reaction:R-DME-9934486] CDH1-associated CTNNA1 binds F-actin - Drosophila melanogaster [Reaction:R-DME-9934294] CDH1-associated CTNNA1 binds VCL - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9934410
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-DME-9764561] Regulation of CDH1 Function
(inferredTo)	[Reaction:R-HSA-9934410] CDH1 forms homotypic trans-dimers