Reactome | Trimethylation of CD274 gene chromatin by MLL1/3 complex

Schema > Reaction > Entries

Trimethylation of CD274 gene chromatin by MLL1/3 complex Show undefined attributes

catalystActivity	[CatalystActivity:10908967] histone H3K4 methyltransferase activity of CD274 gene chromatin:MLL1,MLL3 complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10908969
displayName	Trimethylation of CD274 gene chromatin by MLL1/3 complex
eventOf	[Pathway:R-DME-9909649] Regulation of PD-L1(CD274) transcription - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9909628] Trimethylation of CD274 gene chromatin by MLL1/3 complex - Homo sapiens
input	6 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-DME-9909595] CD274 gene chromatin:MLL1,MLL3 complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Trimethylation of CD274 gene chromatin by MLL1/3 complex
output	6 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-DME-9909596] MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm]
precedingEvent	[Reaction:R-DME-9909646] MLL1,MLL3 complex binding to CD274 gene chromatin - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9909628
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9909649] Regulation of PD-L1(CD274) transcription
(inferredTo)	[Reaction:R-HSA-9909628] Trimethylation of CD274 gene chromatin by MLL1/3 complex

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