Reactome | PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter

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PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter Show undefined attributes

catalystActivity	[CatalystActivity:10905460] histone H3K27 methyltransferase activity of PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10905462
displayName	PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter
eventOf	[Pathway:R-DME-9764725] Negative Regulation of CDH1 Gene Transcription - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9764932] PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter - Homo sapiens
input	6 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-DME-9815907] PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter
output	6 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-DME-9815909] PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9764932
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9764725] Negative Regulation of CDH1 Gene Transcription
(inferredTo)	[Reaction:R-HSA-9764932] PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter

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