Reactome | NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1

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NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 Show undefined attributes

catalystActivity	[CatalystActivity:10905384] ubiquitin protein ligase activity of BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10905386
displayName	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1
eventOf	[Pathway:R-DME-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DME-9762096] Ub,pS335,S338,T NFE2L2 is degraded - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 - Homo sapiens
input	[Complex:R-DME-9762081] BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] 3 × [DefinedSet:R-DME-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1
output	[Complex:R-DME-9762077] BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm]
precedingEvent	[Reaction:R-DME-9762093] BTRC binds p-S344, 347 NFE2L2 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9762091
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
(precedingEvent)	[BlackBoxEvent:R-DME-9762096] Ub,pS335,S338,T NFE2L2 is degraded
(inferredTo)	[Reaction:R-HSA-9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1

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