Reactome | CDK6 inhibitors bind CDK6

Schema > Reaction > Entries

CDK6 inhibitors bind CDK6 Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10905048
displayName	CDK6 inhibitors bind CDK6
eventOf	[Pathway:R-DME-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9754129] CDK6 inhibitors bind CDK6 - Homo sapiens
input	[DefinedSet:R-ALL-9754132] CDK6 inhibitors [nucleoplasm] [DefinedSet:R-DME-9756822] p-T177-CDK6:CCND [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK6 inhibitors bind CDK6
output	[DefinedSet:R-DME-9754128] p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm]
precedingEvent	[Reaction:R-DME-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9754129
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9754119] Drug-mediated inhibition of CDK4/CDK6 activity
(inferredTo)	[Reaction:R-HSA-9754129] CDK6 inhibitors bind CDK6