Reactome | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

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IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Show undefined attributes

compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912224
displayName	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
eventOf	[Pathway:R-DME-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation - Drosophila melanogaster [Reaction:R-DME-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Drosophila melanogaster [Reaction:R-DME-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Drosophila melanogaster [Reaction:R-DME-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-975144
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
(inferredTo)	[Pathway:R-HSA-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

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