Reactome | Mature S-Farn-Me KRAS4B translocates to plasma membrane

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Mature S-Farn-Me KRAS4B translocates to plasma membrane Show undefined attributes

category	omitted
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10903913
displayName	Mature S-Farn-Me KRAS4B translocates to plasma membrane
eventOf	[Pathway:R-DME-9648002] RAS processing - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-9653503] KRAS4B is phosphorylated on serine 181 - Drosophila melanogaster [Reaction:R-DME-9653585] S-Farn-Me KRAS4B binds calmodulin - Drosophila melanogaster [Reaction:R-DME-9649733] mature p21 RAS binds GDP - Drosophila melanogaster
inferredFrom	[BlackBoxEvent:R-HSA-9649732] Mature S-Farn-Me KRAS4B translocates to plasma membrane - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-9649690] S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Mature S-Farn-Me KRAS4B translocates to plasma membrane
output	[EntityWithAccessionedSequence:R-DME-9647815] S-Farn-Me KRAS4B [plasma membrane]
precedingEvent	[Reaction:R-DME-9647977] ICMT methylates S-Farn RAS proteins - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9649732
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9648002] RAS processing
(precedingEvent)	[Reaction:R-DME-9653503] KRAS4B is phosphorylated on serine 181 [Reaction:R-DME-9653585] S-Farn-Me KRAS4B binds calmodulin [Reaction:R-DME-9649733] mature p21 RAS binds GDP
(inferredTo)	[BlackBoxEvent:R-HSA-9649732] Mature S-Farn-Me KRAS4B translocates to plasma membrane

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