Reactome | Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate

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Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate Show undefined attributes

catalystActivity	[CatalystActivity:10857601] alanine-glyoxylate transaminase activity of AGXT2 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10857603
displayName	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate
eventOf	[Pathway:R-DME-389661] Glyoxylate metabolism and glycine degradation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5693967] PXLP-K754-GLDC dimer decarboxylates Gly - Drosophila melanogaster
goBiologicalProcess	[GO_BiologicalProcess:15010] glyoxylate metabolic process
inferredFrom	[Reaction:R-HSA-904864] Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate - Homo sapiens
input	[SimpleEntity:R-ALL-904849] glyoxylate [mitochondrial matrix] [SimpleEntity:R-ALL-379697] L-Ala [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate glyoxylate + L-alanine => glycine + pyruvate
output	[SimpleEntity:R-ALL-159549] Gly [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-904864
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-DME-5693967] PXLP-K754-GLDC dimer decarboxylates Gly
(inferredTo)	[Reaction:R-HSA-904864] Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate

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