Reactome | RASA1 binds RAS:GTP

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10900761
displayName	RASA1 binds RAS:GTP
eventOf	[Pathway:R-DME-8849471] PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-8981353] RASA1 stimulates RAS GTPase activity - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-8981355] RASA1 binds RAS:GTP - Homo sapiens
input	[Complex:R-DME-109783] p21 RAS:GTP [plasma membrane] [EntityWithAccessionedSequence:R-DME-186833] vap [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RASA1 binds RAS:GTP
output	[Complex:R-DME-8981350] p21 RAS:GTP:RASA1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8981355
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-8849471] PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
(precedingEvent)	[Reaction:R-DME-8981353] RASA1 stimulates RAS GTPase activity
(inferredTo)	[Reaction:R-HSA-8981355] RASA1 binds RAS:GTP