Reactome | RHOA:GDP [plasma membrane]

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RHOA:GDP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DME-194533] RHOA:GDP:ARHGDIA [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-9012835] GDIs block activation of RHOA - Drosophila melanogaster [Reaction:R-DME-8980691] RHOA GEFs activate RHOA - Drosophila melanogaster [Reaction:R-DME-114544] p115-RhoGEF activation of RHOA - Drosophila melanogaster [Reaction:R-DME-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Drosophila melanogaster [Reaction:R-DME-3928651] NGEF exchanges GTP for GDP on RHOA - Drosophila melanogaster [Reaction:R-DME-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10837158
displayName	RHOA:GDP [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29420] GDP [cytosol] [EntityWithAccessionedSequence:R-DME-194510] RHOA [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-8964174] RHOA:GDP [plasma membrane] - Homo sapiens
maxDepth	2
name	RHOA:GDP
producedByEvent	[Reaction:R-DME-8981637] RHOA GAPs stimulate RHOA GTPase activity - Drosophila melanogaster [Reaction:R-DME-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Drosophila melanogaster [Reaction:R-DME-8849082] ARHGAP35 stimulates RHOA GTPase activity - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8964174
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-DME-8981637] RHOA GAPs stimulate RHOA GTPase activity [Reaction:R-DME-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA [Reaction:R-DME-8849082] ARHGAP35 stimulates RHOA GTPase activity
(input)	[Reaction:R-DME-9012835] GDIs block activation of RHOA [Reaction:R-DME-8980691] RHOA GEFs activate RHOA [Reaction:R-DME-114544] p115-RhoGEF activation of RHOA [Reaction:R-DME-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it [Reaction:R-DME-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth [Reaction:R-DME-3928651] NGEF exchanges GTP for GDP on RHOA
(hasComponent)	[Complex:R-DME-194533] RHOA:GDP:ARHGDIA [plasma membrane]
(inferredTo)	[Complex:R-HSA-8964174] RHOA:GDP [plasma membrane]

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