Reactome | SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex

Schema > Reaction > Entries

SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex Show undefined attributes

category	binding
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10900189
displayName	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex
eventOf	[Pathway:R-DME-8949664] Processing of SMDT1 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8953461] SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-8949227] EMRE [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-DME-8949184] MCU [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-DME-8949153] MCU [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-DME-8949180] MICU1 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-DME-8949166] MICU3 [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex
output	[Complex:R-DME-8949151] MCU complex [mitochondrial inner membrane]
precedingEvent	[Reaction:R-DME-8949649] PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8953461
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8949664] Processing of SMDT1
(inferredTo)	[Reaction:R-HSA-8953461] SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex

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