Reactome | Activated PKC phosphorylates SHC1

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Activated PKC phosphorylates SHC1 Show undefined attributes

catalystActivity	[CatalystActivity:10897523] calcium,diacylglycerol-dependent serine/threonine kinase activity of Activated PRKCA,(PRKCD,PRKCE) [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10897525
displayName	Activated PKC phosphorylates SHC1
eventOf	[Pathway:R-DME-1250196] SHC1 events in ERBB2 signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8934446] Activated PKC phosphorylates SHC1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-DME-912321] phospho-Shc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated PKC phosphorylates SHC1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-DME-8934452] phospho-Shc [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8934446
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1250196] SHC1 events in ERBB2 signaling
(inferredTo)	[Reaction:R-HSA-8934446] Activated PKC phosphorylates SHC1

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