Reactome | HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

Schema > Reaction > Entries

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 Show undefined attributes

catalystActivity	[CatalystActivity:10897145] guanyl-nucleotide exchange factor activity of HPS1:HPS4 [cytosol]
category	transition
compartment	[Compartment:5668575] melanosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10897147
displayName	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38
eventOf	[Pathway:R-DME-8876198] RAB GEFs exchange GTP for GDP on RABs - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8877760] HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-DME-8877756] RAB32,RAB38:GDP:GDIs,CHMs [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38
output	[DefinedSet:R-DME-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-DME-8877758] RAB32,RAB38:GTP [melanosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8877760
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8876198] RAB GEFs exchange GTP for GDP on RABs
(inferredTo)	[Reaction:R-HSA-8877760] HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

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