Reactome | VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane

Schema > BlackBoxEvent > Entries

VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:17938] lysosomal membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10894701
displayName	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane
eventOf	[Pathway:R-DME-8866427] VLDLR internalisation and degradation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8855130] VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane - Homo sapiens
input	[Complex:R-DME-8855134] VLDL:PCSK9:Clathrin:AP2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane
output	[Complex:R-DME-8855135] VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8855130
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8866427] VLDLR internalisation and degradation
(inferredTo)	[BlackBoxEvent:R-HSA-8855130] VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane

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