Reactome | TBC1D16 accelerates GTP hydrolysis by RAB4A

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TBC1D16 accelerates GTP hydrolysis by RAB4A Show undefined attributes

catalystActivity	[CatalystActivity:10894635] GTPase activity of GGC-RAB4A:GTP [cytoplasmic vesicle membrane]
category	transition
compartment	[Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10894642
displayName	TBC1D16 accelerates GTP hydrolysis by RAB4A
eventOf	[Pathway:R-DME-8854214] TBC/RABGAPs - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8854604] TBC1D16 accelerates GTP hydrolysis by RAB4A - Homo sapiens
input	[Complex:R-DME-1458538] GGC-RAB4A:GTP [cytoplasmic vesicle membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TBC1D16 accelerates GTP hydrolysis by RAB4A
output	[Complex:R-DME-8854611] GGC-RAB4A:GDP [cytoplasmic vesicle membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
regulatedBy	[PositiveRegulation:10894643] Positive regulation by 'TBC1D16 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8854604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8854214] TBC/RABGAPs
(inferredTo)	[Reaction:R-HSA-8854604] TBC1D16 accelerates GTP hydrolysis by RAB4A

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