Reactome | NTPDase5 hydrolyzes nucleoside diphosphates

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NTPDase5 hydrolyzes nucleoside diphosphates Show undefined attributes

catalystActivity	[CatalystActivity:10894056] nucleoside diphosphate phosphatase activity of NPTDase5:Ca2+,Mg2+ [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10894058
displayName	NTPDase5 hydrolyzes nucleoside diphosphates
eventOf	[Pathway:R-DME-8850843] Phosphate bond hydrolysis by NTPDase proteins - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-8940074] NT5E:Zn2+ hydrolyses NMN - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-8851356] NTPDase5 hydrolyzes nucleoside diphosphates - Homo sapiens
input	[DefinedSet:R-ALL-8936165] ADP,GDP,CDP,UDP [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	NTPDase5 hydrolyzes nucleoside diphosphates UDP + H2O => UMP + phosphate + H(+) GDP + H2O => GMP + phosphate + H(+) CDP + H2O => CMP + phosphate + H(+) ADP + H2O => AMP + phosphate + H(+)
output	[DefinedSet:R-ALL-8851369] AMP,GMP,CMP,UMP [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-109277] Pi [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8851356
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DME-8940074] NT5E:Zn2+ hydrolyses NMN
(hasEvent)	[Pathway:R-DME-8850843] Phosphate bond hydrolysis by NTPDase proteins
(inferredTo)	[Reaction:R-HSA-8851356] NTPDase5 hydrolyzes nucleoside diphosphates

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