Reactome | PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG

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PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG Show undefined attributes

catalystActivity	[CatalystActivity:10830825] phosphoglycerate kinase activity of PGK complexes [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10830827
displayName	PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG
eventOf	[Pathway:R-DME-70263] Gluconeogenesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-70482] GAPDH tetramers reduce 1,3BPG to GA3P - Drosophila melanogaster [Reaction:R-DME-6798335] BPGM dimer isomerises 1,3BPG to 2,3BPG - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-70486] PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG - Homo sapiens
input	[SimpleEntity:R-ALL-29728] 3PG [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP
output	[SimpleEntity:R-ALL-29800] 1,3BPG [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-DME-71445] PGAM dimers isomerise 2PG to 3PG - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-70486
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-70263] Gluconeogenesis
(precedingEvent)	[Reaction:R-DME-6798335] BPGM dimer isomerises 1,3BPG to 2,3BPG [Reaction:R-DME-70482] GAPDH tetramers reduce 1,3BPG to GA3P
(inferredTo)	[Reaction:R-HSA-70486] PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG

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