Reactome | ARFGAPs stimulate ARF GTPase activity

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ARFGAPs stimulate ARF GTPase activity Show undefined attributes

catalystActivity	[CatalystActivity:10892162] GTPase activity of RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane]
category	transition
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10892164
displayName	ARFGAPs stimulate ARF GTPase activity
eventOf	[Pathway:R-DME-6807878] COPI-mediated anterograde transport - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-6809003] ERGIC-to-Golgi vesicles bind dynein:dynactin - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-6807877] ARFGAPs stimulate ARF GTPase activity - Homo sapiens
input	[Complex:R-DME-6807825] RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ARFGAPs stimulate ARF GTPase activity
output	[Complex:R-DME-6807786] ARF:GDP [cytosol] [DefinedSet:R-DME-6807832] ARFGAP1,2,3 [cytosol] [EntityWithAccessionedSequence:R-DME-6807751] garz [cytosol] [Complex:R-DME-6808903] RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle]
precedingEvent	[Reaction:R-DME-6807875] ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6807877
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-6807878] COPI-mediated anterograde transport
(precedingEvent)	[Reaction:R-DME-6809003] ERGIC-to-Golgi vesicles bind dynein:dynactin
(inferredTo)	[Reaction:R-HSA-6807877] ARFGAPs stimulate ARF GTPase activity