Reactome | Monoubiquitinated PTEN translocates to the nucleus

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Monoubiquitinated PTEN translocates to the nucleus Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10891886
displayName	Monoubiquitinated PTEN translocates to the nucleus
eventOf	[Pathway:R-DME-8948747] Regulation of PTEN localization - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Drosophila melanogaster
inferredFrom	[BlackBoxEvent:R-HSA-6807105] Monoubiquitinated PTEN translocates to the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-6807247] Pten [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Monoubiquitinated PTEN translocates to the nucleus
output	[EntityWithAccessionedSequence:R-DME-6807264] Pten [nucleoplasm]
precedingEvent	[Reaction:R-DME-6807106] PTEN undergoes monoubiquitination - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6807105
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8948747] Regulation of PTEN localization
(precedingEvent)	[Reaction:R-DME-6807118] USP7 deubiquitinates monoubiquitinated PTEN
(inferredTo)	[BlackBoxEvent:R-HSA-6807105] Monoubiquitinated PTEN translocates to the nucleus

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