Reactome | PXLP-K278-PHYKPL tetramer hydrolyses 5PHL

Schema > Reaction > Entries

PXLP-K278-PHYKPL tetramer hydrolyses 5PHL Show undefined attributes

catalystActivity	[CatalystActivity:10884498] lyase activity of PHYKPL tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10884500
displayName	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
eventOf	[Pathway:R-DME-71064] Lysine catabolism - Drosophila melanogaster [Pathway:R-DME-1442490] Collagen degradation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5696408] PXLP-K278-PHYKPL tetramer hydrolyses 5PHL - Homo sapiens
input	[SimpleEntity:R-ALL-5696409] 5PHL [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K278-PHYKPL tetramer hydrolyses 5PHL 5R)-5-phosphooxy-L-lysine + H2O => (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate
output	[SimpleEntity:R-ALL-113556] 2AMAS [mitochondrial matrix] [SimpleEntity:R-ALL-113561] NH4+ [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-DME-6788611] HYKK phosphorylates 5HLYS - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5696408
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1442490] Collagen degradation [Pathway:R-DME-71064] Lysine catabolism
(precedingEvent)	[Reaction:R-DME-70941] alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
(inferredTo)	[Reaction:R-HSA-5696408] PXLP-K278-PHYKPL tetramer hydrolyses 5PHL

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