Reactome | MDC1 associates with gamma-H2AFX at nuclear foci

Schema > Reaction > Entries

MDC1 associates with gamma-H2AFX at nuclear foci Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10883799
displayName	MDC1 associates with gamma-H2AFX at nuclear foci
eventOf	[Pathway:R-DME-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5693536] ATM phosphorylates MDC1 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5693583] MDC1 associates with gamma-H2AFX at nuclear foci - Homo sapiens
input	[Complex:R-DME-5682180] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] [Complex:R-DME-5682522] MDC1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MDC1 associates with gamma-H2AFX at nuclear foci
output	[Complex:R-DME-5693594] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm]
precedingEvent	[Reaction:R-DME-5683967] EYA1-4 dephosphorylates tyrosine Y142 of H2AFX - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5693583
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-DME-5693536] ATM phosphorylates MDC1
(inferredTo)	[Reaction:R-HSA-5693583] MDC1 associates with gamma-H2AFX at nuclear foci

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