Reactome | DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10882156] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-DME-5683967] EYA1-4 dephosphorylates tyrosine Y142 of H2AFX - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10882155
displayName	DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
hasComponent	[Complex:R-DME-5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-DME-5683972] p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5683952] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] - Homo sapiens
maxDepth	5
name	DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome
producedByEvent	[Reaction:R-DME-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5683952
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DME-5683967] EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
(physicalEntity)	[CatalystActivity:10882156] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(output)	[Reaction:R-DME-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs
(inferredTo)	[Complex:R-HSA-5683952] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]

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