Reactome | "Activator" RAF:YWHAB dimer binds RAS:GTP

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"Activator" RAF:YWHAB dimer binds RAS:GTP Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10711695
displayName	"Activator" RAF:YWHAB dimer binds RAS:GTP
eventOf	[Pathway:R-DME-5673000] RAF activation - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP - Homo sapiens
input	[Complex:R-DME-5672710] 'activator' RAF:YWHAB dimer [cytosol] [Complex:R-DME-109783] p21 RAS:GTP [plasma membrane]
isInDisease	false
isInferred	true
name	"Activator" RAF:YWHAB dimer binds RAS:GTP
output	[Complex:R-DME-5672729] p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane]
precedingEvent	[Reaction:R-DME-5672965] RAS GEFs promote RAS nucleotide exchange - Drosophila melanogaster [Reaction:R-DME-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Drosophila melanogaster
regulatedBy	[PositiveRegulation:10711696] Positive regulation by 'PHB [cytosol]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5672950
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5673000] RAF activation
(precedingEvent)	[Reaction:R-DME-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
(inferredTo)	[Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP