Reactome | activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DME-9657592] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-9657608] Single mechanism MAPK inhibitors bind phosphorylated MAPK - Drosophila melanogaster [Reaction:R-DME-5672980] Dissociation of RAS:RAF complex - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10881408
displayName	activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
hasComponent	[DefinedSet:R-DME-5672721] p-2S MAP2K homo/heterodimers [cytosol] [DefinedSet:R-DME-169289] p-T,Y MAPKs [cytosol] [Complex:R-DME-5672718] p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] [CandidateSet:R-DME-5672717] RAF/MAPK scaffolds [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] - Homo sapiens
maxDepth	6
name	activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex
producedByEvent	[Reaction:R-DME-5672973] MAP2Ks phosphorylate MAPKs - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5672724
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DME-9657608] Single mechanism MAPK inhibitors bind phosphorylated MAPK [Reaction:R-DME-5672980] Dissociation of RAS:RAF complex
(hasComponent)	[Complex:R-DME-9657592] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane]
(output)	[Reaction:R-DME-5672973] MAP2Ks phosphorylate MAPKs
(inferredTo)	[Complex:R-HSA-5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]

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