Reactome | PI-3K cascade:FGFR3

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PI-3K cascade:FGFR3 Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911410
displayName	PI-3K cascade:FGFR3
eventOf	[Pathway:R-DME-5654708] Downstream signaling of activated FGFR3 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Drosophila melanogaster [Reaction:R-DME-5654637] Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 - Drosophila melanogaster [Reaction:R-DME-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-DME-5654641] Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Drosophila melanogaster [Reaction:R-DME-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-5654710] PI-3K cascade:FGFR3 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PI-3K cascade:FGFR3
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5654710
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5654708] Downstream signaling of activated FGFR3
(inferredTo)	[Pathway:R-HSA-5654710] PI-3K cascade:FGFR3

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