Reactome | Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2

Schema > Reaction > Entries

Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 Show undefined attributes

catalystActivity	[CatalystActivity:10880272] MAP kinase activity of p-T,Y MAPK dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10880278
displayName	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2
eventOf	[Pathway:R-DME-5654732] Negative regulation of FGFR3 signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5654565] Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 - Homo sapiens
input	[Complex:R-DME-5654180] Activated FGFR3:FRS2 [plasma membrane] 8 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2
output	[Complex:R-DME-5654301] Activated FGFR3:p-8T-FRS2 [plasma membrane] 8 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-DME-5674385] p-T,Y MAPKs dimerize - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5654565
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5654732] Negative regulation of FGFR3 signaling
(inferredTo)	[Reaction:R-HSA-5654565] Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2

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