Reactome | PKN1:AR complex binds promoters of KLK2 and KLK3 genes

Schema > Reaction > Entries

PKN1:AR complex binds promoters of KLK2 and KLK3 genes Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10879502
displayName	PKN1:AR complex binds promoters of KLK2 and KLK3 genes
eventOf	[Pathway:R-DME-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5625774] PKN1:AR complex binds promoters of KLK2 and KLK3 genes - Homo sapiens
input	[Complex:R-DME-5625764] KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] [Complex:R-DME-5625736] p-T774-PKN1:AR:Androgen [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PKN1:AR complex binds promoters of KLK2 and KLK3 genes
output	[Complex:R-DME-5625776] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm]
precedingEvent	[Reaction:R-DME-5625738] p-T774-PKN1:AR:Androgen complex translocates to the nucleus - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5625774
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(precedingEvent)	[Reaction:R-DME-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
(inferredTo)	[Reaction:R-HSA-5625774] PKN1:AR complex binds promoters of KLK2 and KLK3 genes

Cite Us!