Reactome | AKR1C3 reduces atRAL to atROL

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AKR1C3 reduces atRAL to atROL Show undefined attributes

catalystActivity	[CatalystActivity:10878774] all-trans-retinol dehydrogenase (NADP+) activity of AKR1C3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10878776
displayName	AKR1C3 reduces atRAL to atROL
eventOf	[Pathway:R-DME-5365859] RA biosynthesis pathway - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5615668] AKR1C3 reduces atRAL to atROL - Homo sapiens
input	[SimpleEntity:R-ALL-975622] atRAL [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AKR1C3 reduces atRAL to atROL
output	[SimpleEntity:R-ALL-975599] atROL [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5615668
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5365859] RA biosynthesis pathway
(inferredTo)	[Reaction:R-HSA-5615668] AKR1C3 reduces atRAL to atROL

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