Reactome | HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA

Schema > Reaction > Entries

HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10856315] very-long-chain 3-oxoacyl-CoA reductase activity of HSD17B3,12 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10856317
displayName	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA
eventOf	[Pathway:R-DME-75876] Synthesis of very long-chain fatty acyl-CoAs - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5676637] PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-548818] HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-548812] 3OOD-CoA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + NADPH + H+ => 3-hydroxyoctadecanoyl-CoA + NADP+
output	[SimpleEntity:R-ALL-548836] 3HODC-CoA [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-DME-548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-548818
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-75876] Synthesis of very long-chain fatty acyl-CoAs
(precedingEvent)	[Reaction:R-DME-5676637] PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA
(inferredTo)	[Reaction:R-HSA-548818] HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA

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