Reactome | TET1,2,3 and TDG demethylate DNA

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TET1,2,3 and TDG demethylate DNA Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912728
displayName	TET1,2,3 and TDG demethylate DNA
eventOf	[Pathway:R-DME-212165] Epigenetic regulation of gene expression - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9907540] chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-5220959] TDG excises 5-formylcytosine - Drosophila melanogaster [Reaction:R-DME-5221061] TDG excises 5-carboxylcytosine - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-5221030] TET1,2,3 and TDG demethylate DNA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TET1,2,3 and TDG demethylate DNA Active DNA Demethylation by TET1,2,3 Oxidative demethylation of DNA
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5221030
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-212165] Epigenetic regulation of gene expression
(inferredTo)	[Pathway:R-HSA-5221030] TET1,2,3 and TDG demethylate DNA

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