Reactome | PDK1 phosphorylates PKC

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PDK1 phosphorylates PKC Show undefined attributes

catalystActivity	[CatalystActivity:10876522] protein serine/threonine kinase activity of PDPK1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10876524
displayName	PDK1 phosphorylates PKC
eventOf	[Pathway:R-DME-5218921] VEGFR2 mediated cell proliferation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5218805] PKC autophosphorylates - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5218821] PDK1 phosphorylates PKC - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-DME-5218761] PKCA,PKCB,PKCD,PKCZ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PDK1 phosphorylates PKC
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-DME-5218754] p-PKCA,p-PKCB,p-PKCZ,p-PKCD [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5218821
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5218921] VEGFR2 mediated cell proliferation
(precedingEvent)	[Reaction:R-DME-5218805] PKC autophosphorylates
(inferredTo)	[Reaction:R-HSA-5218821] PDK1 phosphorylates PKC

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