Reactome | Regulation of mRNA stability by proteins that bind AU-rich elements

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Regulation of mRNA stability by proteins that bind AU-rich elements Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912112
displayName	Regulation of mRNA stability by proteins that bind AU-rich elements
eventOf	[TopLevelPathway:R-DME-8953854] Metabolism of RNA - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:171831] regulation of mRNA stability
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DME-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Drosophila melanogaster [Pathway:R-DME-450385] Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA - Drosophila melanogaster [Pathway:R-DME-450513] Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA - Drosophila melanogaster [Pathway:R-DME-450604] KSRP (KHSRP) binds and destabilizes mRNA - Drosophila melanogaster [Pathway:R-DME-450520] HuR (ELAVL1) binds and stabilizes mRNA - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-450531] Regulation of mRNA stability by proteins that bind AU-rich elements - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Regulation of mRNA stability by proteins that bind AU-rich elements
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-450531
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-DME-8953854] Metabolism of RNA
(inferredTo)	[Pathway:R-HSA-450531] Regulation of mRNA stability by proteins that bind AU-rich elements

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