Reactome | Membrane depolarization upon activation of Ca impermeable AMPA receptors

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Membrane depolarization upon activation of Ca impermeable AMPA receptors Show undefined attributes

catalystActivity	[CatalystActivity:10850062] excitatory extracellular ligand-gated monoatomic ion channel activity of Ca impermeable AMPA receptor ligand complex [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10853206
displayName	Membrane depolarization upon activation of Ca impermeable AMPA receptors
eventOf	[Pathway:R-DME-438066] Unblocking of NMDA receptors, glutamate binding and activation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-438037] Membrane depolarization upon activation of Ca impermeable AMPA receptors - Homo sapiens
input	[SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Membrane depolarization upon activation of Ca impermeable AMPA receptors
output	[SimpleEntity:R-ALL-83910] Na+ [cytosol]
regulatedBy	[PositiveRegulation:10853207] Positive regulation by 'Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-438037
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-438066] Unblocking of NMDA receptors, glutamate binding and activation
(inferredTo)	[Reaction:R-HSA-438037] Membrane depolarization upon activation of Ca impermeable AMPA receptors

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