Reactome | SLC8A1,2,3 exchange 3Na+ for Ca2+

Schema > Reaction > Entries

SLC8A1,2,3 exchange 3Na+ for Ca2+ Show undefined attributes

catalystActivity	[CatalystActivity:10851099] calcium:sodium antiporter activity of SLC8A1,2,3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10851101
displayName	SLC8A1,2,3 exchange 3Na+ for Ca2+
eventOf	[Pathway:R-DME-5578775] Ion homeostasis - Drosophila melanogaster [Pathway:R-DME-418359] Reduction of cytosolic Ca++ levels - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-425661] SLC8A1,2,3 exchange 3Na+ for Ca2+ - Homo sapiens
input	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] 3 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC8A1,2,3 exchange 3Na+ for Ca2+
output	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] 3 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
regulatedBy	[NegativeRegulation:10851102] Negative regulation by 'CALM1 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-425661
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5578775] Ion homeostasis [Pathway:R-DME-418359] Reduction of cytosolic Ca++ levels [Pathway:R-DME-425561] Sodium/Calcium exchangers
(inferredTo)	[Reaction:R-HSA-425661] SLC8A1,2,3 exchange 3Na+ for Ca2+