Reactome | COX15 transforms heme O to heme A

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COX15 transforms heme O to heme A Show undefined attributes

catalystActivity	[CatalystActivity:10872383] heme A synthase activity of COX15 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10872385
displayName	COX15 transforms heme O to heme A
eventOf	[Pathway:R-DME-189451] Heme biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2995334] COX15 transforms heme O to heme A - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-9865393] heme O [mitochondrial inner membrane] 2 × [SimpleEntity:R-ALL-9757044] hydrogen acceptor [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	COX15 transforms heme O to heme A 2 A + Fe(II)-heme o + H2O => 2 AH2 + Fe(II)-heme a
output	[SimpleEntity:R-ALL-9864492] heme A [mitochondrial inner membrane] 2 × [SimpleEntity:R-ALL-9757039] hydrogen donor [mitochondrial matrix]
precedingEvent	[Reaction:R-DME-2995330] COX10 transforms heme to heme O - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2995334
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-189451] Heme biosynthesis
(inferredTo)	[Reaction:R-HSA-2995334] COX15 transforms heme O to heme A

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