Reactome | Downregulation of SMAD2/3:SMAD4 transcriptional activity

Schema > Pathway > Entries

Downregulation of SMAD2/3:SMAD4 transcriptional activity Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911352
displayName	Downregulation of SMAD2/3:SMAD4 transcriptional activity
eventOf	[Pathway:R-DME-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:17800] negative regulation of transcription by RNA polymerase II
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Drosophila melanogaster [BlackBoxEvent:R-DME-2186767] Degradation of ubiquitinated SKI/SKIL - Drosophila melanogaster [BlackBoxEvent:R-DME-870477] Ubiquitinated SMAD4 translocates from the nucleus to the cytosol - Drosophila melanogaster [Reaction:R-DME-870479] USP9X (FAM) binds to ubiquitinated SMAD4 - Drosophila melanogaster [Reaction:R-DME-870437] USP9X (FAM) deubiquitinates SMAD4 - Drosophila melanogaster [Reaction:R-DME-2176491] NEDD4L binds phosphorylated linker region of SMAD2/3 - Drosophila melanogaster [Reaction:R-DME-2176502] NEDD4L ubiquitinates SMAD2/3 - Drosophila melanogaster [BlackBoxEvent:R-DME-2176503] Degradation of SMAD2/3:SMAD4 complex - Drosophila melanogaster [Reaction:R-DME-2179274] SMURF2 binds SMAD3 phosphorylated in the linker region - Drosophila melanogaster [Reaction:R-DME-2179276] SMURF2 monoubiquitinates SMAD3 - Drosophila melanogaster [Reaction:R-DME-5252001] ATP1B4 binds SNW1 - Drosophila melanogaster [Reaction:R-DME-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Drosophila melanogaster [Reaction:R-DME-209055] PPM1A dephosphorylates nuclear SMAD2/3 - Drosophila melanogaster [Reaction:R-DME-2187395] Dephosphorylated SMAD2/3 translocates to the cytosol - Drosophila melanogaster [BlackBoxEvent:R-DME-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling - Drosophila melanogaster [Reaction:R-DME-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Downregulation of SMAD2/3:SMAD4 transcriptional activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2173795
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
(inferredTo)	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity

© 2026 Reactome

Cite Us!