Reactome | COS binds to SMO

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COS binds to SMO Show undefined attributes

authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:216199] Williams, MG, 2008-03-11 15:41:17
dbId	216222
displayName	COS binds to SMO
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209338] Assembly of the 'signalling complexes' - Drosophila melanogaster
figure	[Figure:216170] /figures/DrosHHB15.jpg
followingEvent	[Reaction:R-DME-209178] N-HH binds to PTC receptor complex - Drosophila melanogaster
input	[Complex:R-DME-216188] COS:CI:FU [cytosol] [EntityWithAccessionedSequence:R-DME-206086] SMO [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208072] Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2 [LiteratureReference:208117] Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog [LiteratureReference:208259] Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail [LiteratureReference:208191] Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 [LiteratureReference:216132] The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	COS binds to SMO
output	[Complex:R-DME-216146] SMO:COS:CI:FU [plasma membrane]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-216222
summation	[Summation:216266] SMO:COS:FU:CI complexes are present prior to Hedgehog signal...

Referrals

(hasEvent)	[Pathway:R-DME-209338] Assembly of the 'signalling complexes'
(precedingEvent)	[Reaction:R-DME-209178] N-HH binds to PTC receptor complex