Reactome | 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

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20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 Show undefined attributes

catalystActivity	[CatalystActivity:10870110] 20-hydroxy-leukotriene B4 omega oxidase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10870112
displayName	20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3
eventOf	[Pathway:R-DME-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-2161792] 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 - Homo sapiens
input	[SimpleEntity:R-ALL-2161636] 20OH-LTB4 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 20-hydroxy-leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:R-ALL-2142740] 20cho-LTB4 [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-DME-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2161745
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(precedingEvent)	[Reaction:R-DME-2161792] 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3
(inferredTo)	[Reaction:R-HSA-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

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