Reactome | Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)

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Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) Show undefined attributes

catalystActivity	[CatalystActivity:10845755] guanyl-nucleotide exchange factor activity of SOS-1 bound to Tie2:Grb2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10845757
displayName	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
eventOf	[Pathway:R-DME-210993] Tie2 Signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-DME-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-DME-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-DME-210974] Interaction of SOS-1 to Tie2 bound Grb2 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-210977
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-210993] Tie2 Signaling
(inferredTo)	[Reaction:R-HSA-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)

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