Reactome | DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine

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DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine Show undefined attributes

catalystActivity	[CatalystActivity:10845004] deoxyhypusine synthase activity of DHPS tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10845008
displayName	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine
eventOf	[Pathway:R-DME-204626] Hypusine synthesis from eIF5A-lysine - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-204662] DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-204647] DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-3006308] eEF5 [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-204635] SPM [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane
output	[SimpleEntity:R-ALL-204628] 1,3-diaminopropane [cytosol] [EntityWithAccessionedSequence:R-DME-3006309] eEF5 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-204647
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-204626] Hypusine synthesis from eIF5A-lysine
(precedingEvent)	[Reaction:R-DME-204662] DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A
(inferredTo)	[Reaction:R-HSA-204647] DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine

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