Reactome | Elongation of arachidonyl-CoA to docosatetraenoyl-CoA

Schema > Reaction > Entries

Elongation of arachidonyl-CoA to docosatetraenoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10869111] fatty acid elongase activity of ELOVL5/ELOVL2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10869113
displayName	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
eventOf	[Pathway:R-DME-2046105] Linoleic acid (LA) metabolism - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-2046095] Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-2046083] Elongation of arachidonyl-CoA to docosatetraenoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-2046053] AA-CoA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2046066] Malonyl-CoA [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH [ELOVL5]
output	[SimpleEntity:R-ALL-159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-162743] CoA-SH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2046060] DTA-CoA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2046083
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2046105] Linoleic acid (LA) metabolism
(precedingEvent)	[Reaction:R-DME-2046095] Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA
(inferredTo)	[Reaction:R-HSA-2046083] Elongation of arachidonyl-CoA to docosatetraenoyl-CoA

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