Reactome | Caspase-mediated cleavage of Desmoglein 3

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Caspase-mediated cleavage of Desmoglein 3 Show undefined attributes

catalystActivity	[CatalystActivity:10843668] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10843759
displayName	Caspase-mediated cleavage of Desmoglein 3
eventOf	[Pathway:R-DME-351906] Apoptotic cleavage of cell adhesion proteins - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-201631] Caspase-mediated cleavage of Desmoglein 3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-201590] CadN [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Caspase-mediated cleavage of Desmoglein 3
output	[EntityWithAccessionedSequence:R-DME-202797] CadN [cytosol] [EntityWithAccessionedSequence:R-DME-202803] CadN [plasma membrane]
precedingEvent	[Reaction:R-DME-114252] Cleavage of Procaspase-3 by the apoptosome - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-201631
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-351906] Apoptotic cleavage of cell adhesion proteins
(inferredTo)	[Reaction:R-HSA-201631] Caspase-mediated cleavage of Desmoglein 3

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