Reactome | GRB2 events in ERBB2 signaling

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912346
displayName	GRB2 events in ERBB2 signaling
eventOf	[Pathway:R-DME-1227986] Signaling by ERBB2 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers - Drosophila melanogaster [Reaction:R-DME-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-1963640] GRB2 events in ERBB2 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	GRB2 events in ERBB2 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1963640
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-1227986] Signaling by ERBB2
(inferredTo)	[Pathway:R-HSA-1963640] GRB2 events in ERBB2 signaling

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