Reactome | Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione

Schema > Reaction > Entries

Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione Show undefined attributes

catalystActivity	[CatalystActivity:10842758] 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10842760
displayName	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione
eventOf	[Pathway:R-DME-193993] Mineralocorticoid biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-196350] Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione - Homo sapiens
input	[SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-193103] PREG [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione Pregnenolone + NAD+ => pregn-5-ene-3,20-dione + NADH + H+
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-196344] pregn-5-ene-3,20-dione [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-196350
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-193993] Mineralocorticoid biosynthesis
(precedingEvent)	[Reaction:R-DME-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone
(inferredTo)	[Reaction:R-HSA-196350] Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione

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