Reactome | 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]

Schema > Reaction > Entries

4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] Show undefined attributes

catalystActivity	[CatalystActivity:10842619] Delta14-sterol reductase activity of LBR [nuclear envelope]
category	transition
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10842621
displayName	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]
eventOf	[Pathway:R-DME-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-194674] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] - Homo sapiens
input	[SimpleEntity:R-ALL-194681] 4,4DMCHtOL [nuclear envelope] [SimpleEntity:R-ALL-194688] H+ [nuclear envelope] [SimpleEntity:R-ALL-194725] NADPH [nuclear envelope]
isInDisease	false
isInferred	true
maxDepth	1
name	4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)
output	[SimpleEntity:R-ALL-194704] 14DMLANOL [nuclear envelope] [SimpleEntity:R-ALL-194668] NADP+ [nuclear envelope]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-194674
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(inferredTo)	[Reaction:R-HSA-194674] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]

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