Reactome | TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)

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TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) Show undefined attributes

catalystActivity	[CatalystActivity:10842421] long-chain fatty acid-CoA ligase activity of SLC27A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10842495
displayName	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)
eventOf	[Pathway:R-DME-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193727] TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-193762] TetraHCA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) TetraHCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
output	[SimpleEntity:R-ALL-193741] 25(R) TetraHCA-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-193727
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(inferredTo)	[Reaction:R-HSA-193727] TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)

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