Reactome | Estrogen biosynthesis

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Estrogen biosynthesis Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911520
displayName	Estrogen biosynthesis
eventOf	[Pathway:R-DME-196071] Metabolism of steroid hormones - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21394] estrogen biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-193143] CYP19A1 hydroxylates TEST to EST17b - Drosophila melanogaster [Reaction:R-DME-193060] CYP19A1 hydroxylates ANDST to E1 - Drosophila melanogaster [Reaction:R-DME-9707353] CYP19A1 binds Aromatase inhibitors - Drosophila melanogaster [Reaction:R-DME-5693390] HSD17B11 dehydrogenates EST17b to E1 - Drosophila melanogaster [Reaction:R-DME-5696822] AKR1B15 reduces EST17b to E1 - Drosophila melanogaster [Reaction:R-DME-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-193144] Estrogen biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Estrogen biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-193144
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-196071] Metabolism of steroid hormones
(inferredTo)	[Pathway:R-HSA-193144] Estrogen biosynthesis

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