Reactome | IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen

Schema > Reaction > Entries

IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen Show undefined attributes

catalystActivity	[CatalystActivity:10864932] inositol hexakisphosphate 3-phosphatase activity of MINPP1 [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10864934
displayName	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
eventOf	[Pathway:R-DME-1855231] Synthesis of IPs in the ER lumen - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-1855225] IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen - Homo sapiens
input	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2024018] IP6 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
output	[SimpleEntity:R-ALL-2564836] I(1,2,4,5,6)P5 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113551] Pi [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1855225
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1855231] Synthesis of IPs in the ER lumen
(precedingEvent)	[Reaction:R-DME-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen
(inferredTo)	[Reaction:R-HSA-1855225] IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen

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