Reactome | EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10841049] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-DME-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10841048
displayName	EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
hasComponent	2 × [Complex:R-DME-182910] CBL:GRB2 [cytosol] [Complex:R-DME-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] - Homo sapiens
maxDepth	3
name	EGF-like ligands:p-6Y-EGFR:CBL:GRB2
producedByEvent	[Reaction:R-DME-183067] Localization of CBL:GRB2 to the membrane - Drosophila melanogaster [Reaction:R-DME-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-182928
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DME-183058] Phosphorylation of CBL (EGFR:GRB2:CBL)
(physicalEntity)	[CatalystActivity:10841049] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
(output)	[Reaction:R-DME-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix [Reaction:R-DME-183067] Localization of CBL:GRB2 to the membrane
(inferredTo)	[Complex:R-HSA-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]

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